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We are excited to bring you this year’s anniversary symposium, comprising 11 exceptional scientific sessions and 13 award talks that cover a wide range of scientific achievements in the field of protein science. Our program committee, chaired by Jeanne Hardy, Ph.D, has convened a host of stimulating speakers and topical areas of current research. This year’s symposium continues our commitment to open participation, with a number of symposium talks coming from contributed sessions and speakers across a broad range of topics. 

Register for PS35. Within 24 hours of registering, you can access our virtual platform, which includes our full program & essential meeting information. Not able to join us live? Registrants will have access to on-demand session content  for 3 months post symposium.

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Plenary Speakers

2021 TPS Award Winners

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Bruno Correia, Ph.D.
2021 Protein Science Young Investigator Award 

Expanding the Universe of Functional Proteins by Computational Design - Examples on Antigen Design and Cell Engineering

Toshiya Endo, Ph.D.
2021 Hans Neurath Award
Protein Machineries that Make and Maintain Mitochondria
Sheila Jaswal, Ph.D.
2021 Carl Branden Award
A Quarter Century of Being Human in Protein Science
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Amy Rosenzweig, Ph.D.
2021 Hans Neurath Award
Copper-dependent Biological Methane Oxidation
Janet Smith, Ph.D.
2021 Dorothy Crowfoot Hodgkin Award
Flavivirus NS1: New Fold and New Functions for an Enigmatic Virulence Factor
Lei Wang, Ph.D.
2021 Emil Thomas Kaiser Award

Genetically Encoded Latent Bioreactive Amino Acids: New Covalent Bonds for Proteins and Covalent Protein Drugs

2020 and 2019 TPS Award Winners

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Catherine Drennan, Ph.D.
2020 Dorothy Crowfoot Hodgkin Award 

Capturing Snapshots of Ribonucleotide Reductase in Action

Karen Fleming, Ph.D.
2020 Carl Branden Award

Chaperoning Unfolded Membrane Proteins

Martin Gruebele, Ph.D.
2020 Hans Neurath Award 

Protein Folding & Interactions:
From the Computer Into the Test Tube & on to the Cell

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Mohammad Seyedsayamdost, Ph.D.
2020 Protein Science Young Investigator Award  

New Reactions Catalyzed by Metalloenzymes in Natural Product Biosynthetic Pathways

Stephen Sligar, Ph.D.
2020 Christian B. Anfinsen Award

Revealing the Structure & Function of Membrane Proteins

Shuguang Zhang, Ph.D.
2020 Emil Thomas Kaiser Award

Self-Assembling Peptides: 
From a Discovery in a Yeast Protein to Diverse Uses & Beyond

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Minoru Kanehisa, Ph.D.
2019 Carl Branden Award
Toward Understanding the Origin & Evolution of Cellular Organisms & Viruses

Preliminary Program and Speakers

Session Topic 1: Cryo-EM: Beyond Single Particle Reconstruction

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Mimi Ho, Ph.D.
Columbia University
Amédée des Georges, Ph.D.
City University of New York
Radostin Danev, Ph.D.
University of Tokyo
Endogenous Structural Biology Approaches for Challenging Systems Peering Into Conformational Ensembles of the Ryanodine Receptor With Cryo-EM Pushing the Limits of Cryo-EM for G Protein-coupled Receptors
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Jungsan (J.) Sohn, Ph.D., MD
Johns Hopkins University
Katarina Meze, Ph.D.
Cold Spring Harbor Laboratory
Gabriel Lander, Ph.D.
Scripps Research Institute
The Signaling Direction, Order, & Specificity of the AIM2-ASC Inflammasome The 3’-5’ Exonuclease Dis3L2 Undergoes Conformational Dynamics During Structured RNA Degradation CHAIR

Session Topic 2: New Protein Post-Translational Modifications

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Eranthie Weerapana, Ph.D.
Boston College

Ian Maze, Ph.D.
Icahn School of Medicine

Hening Lin, Ph.D.
Cornell University

Chemical-proteomic Strategies to Investigate Reactive Cysteines Protein Monoaminylation in Brain: Novel Mechanisms of Neural Development, Plasticity & Disease Post-translational Modification Cycles in Cell Signaling & Disease
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Renã A. S. Robinson, Ph.D.
Vanderbilt University
Sonya Neal, Ph.D.
University of California, San Diego
Alex Guseman, Ph.D.
University of Pittsburgh
Proteomic Platforms for Endogenous Measurement of
S-Nitrosylation in Aging Models

The Role of Derlin Rhomboid Pseudoproteases in ERADicating Misfolded Membrane Proteins

Assessing the Structures and Interactions of γD-Crystallin Deamidation Variants
Jean Baum, Ph.D.
Rutgers University

Session Topic 3: Targeted Protein Degradation

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Katelyn Cassidy, Ph.D.
Angela Cacace, Ph.D.
Nicolas Thomä, Ph.D.
Friedrich Miescher Institute
MS-based Proteomics: a Central, Multifaceted Resource for the Advancement of Targeted Protein Degradation Projects Arvinas Targeted Degrader Discovery Engine Haven’t Got a Glue: Translating Molecular Insights on Chromatin and Ubiquitin Ligases into Novel Therapeutics
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Scott Eron, Ph.D.
C4 Therapeutics
Jiale Du, Ph.D.
University of Massachusetts, Amherst
Jeanne Hardy, Ph.D.
University of Massachusetts, Amherst
Finding a Way Out of the Labyrinth: Degrader-Induced Ternary Complex Modelling A Cryptic K48 Ubiquitin Chain-Specific Site on the Proteasome-Associated Deubiquitinase UCH37/UCHL5 Is Required for Degradation CHAIR

Session Topic 4: Protein Structures Through the Lens of Machine Learning

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John Jumper, Ph.D.

David Koes, Ph.D.
University of Pittsburgh

Heather Kulik, Ph.D.
High Accuracy Protein Structure Prediction Using Deep Learning An Atomistic View of Deep Protein Structure Prediction What Can Machine Learning & Big Data Teach Us About Metalloenzymes?
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Daniel Schmidt, Ph.D.
University of Minnesota
Carlos Outeirall Rubiera, Ph.D.
University of Oxford
Jeanne Hardy, Ph.D.
University of Massachusetts, Amherst
Applying Machine Learning to Understand the Biophysical Basis of Protein Domain Compatibility How Good are Protein Structure Prediction Methods at Predicting Folding Pathways? CHAIR

Session Topic 5: Protein Evolution, Design and Selection

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Donald Hilvert, Ph.D.
ETH Zurich
Janet Thornton, Ph.D.
Lydia Contreras, Ph.D.
University of Texas at Austin
Evolving Virus-like Nucleocapsids From a Bacterial Enzyme Computational Enzymology: The Structure, Function and Evolution of Enzymes New Approaches for Identifying & Designing Novel RNA readers
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Liangcai Gu, Ph.D.
University of Washington

Sergio Romero-Romero, Ph.D.
University of Bayreuth
LAPS Representative
Nikolay V. Dokholyan, Ph.D.
Penn State College of Medicine
Efficient, Generalizable Approaches for Creating Chemogenetic and Optogenetic Sensors
Exploring the Stability Panorama of de novo TIM Barrels by Protein Design CHAIR

Session Topic 6: Novel Approaches to Observe Proteins in Their Natural Environment

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Rina Rosenzweig, Ph.D.
Weizmann Institute of Science
Miroslava Schaffer, Ph.D.
Max Planck Institute
Lisa Jones, Ph.D.
University of Maryland
The Roles of Hsp40 Chaperones in Health & Disease Cryo-FIB Sample Preparation Methods for Tissue & Cells in Structure Biology Studies at Molecular Resolution Development of In-Cell Protein Footprinting Coupled with Mass Spectrometry for Proteome-Wide Biology
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Stephen D. Fried, Ph.D.
Johns Hopkins University
Whitney Costello, Ph.D.
UT Southwestern Medical Center

Gabriel Lander, Ph.D.
Scripps Research Institute

Probing the Proteome’s Refoldability under Cellular-like Conditions with Mass Spectrometry Enabling Structural Studies of Metastable Proteins within Cellular Milieu via Dynamic Nuclear Polarization NMR CHAIR

Session Topic 7: Allostery & Dynamics in Protein Function

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Corey Wilson, Ph.D.
Georgia Institute of Technology
Rachelle Gaudet, Ph.D.
Harvard University
Andrew Woolley, Ph.D.
University of Toronto
Transcriptional Programming - Engineering Intelligent Biological Systems Mechanics of an Nramp Family Transition Metal Transporter Harnessing Photo-Switchable Proteins
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David Boehr, Ph.D.
The Pennsylvania State University
Heather Masson-Forsythe, Ph.D.
Oregon State University
Woody Sherman, Ph.D.
Silicon Therapeutics
Differences in Conformational Dynamics Between a Virus Polyprotein and its Fully Processed CounterpartsEexpands the Functional Proteome A Dancing Duplex: The SARS-CoV-2 Nucleocapsid Phosphoprotein’s Multivalent Binding to RNA CHAIR

Session Topic 8: Diffraction Methods are Alive and Well

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Jose Rodriguez, Ph.D.
University of California Los Angeles

Carolyn Larabell, Ph.D.
University of California San Francisco

Eriko Nango, Ph.D.
Tohuku University
New Approaches in Electron Diffraction for Visualizing Molecules with Atomic Detail Imaging Membraneless Organelles and Biomolecular Condensates in the Native State Protein Structural Dynamics Revealed by Molecular Movie Analysis
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Karsten Melcher, Ph.D.
Van Andel Institute

Michelle Fry, Ph.D.
California Institute of Technology
Sarah Perry, Ph.D.
University of Massachusetts, Amherst
Structure of the AMPK Complex in its Inactive ATP-bound State The ATPase Cycle of Get3 from a Human Pathogen CHAIR

Session Topic 9: Measuring Forces of Biological Systems

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Michelle Wang, Ph.D.
Cornell University

Andrea Candelli, Ph.D.

Khalid Salaita, Ph.D.
Emory University

DNA Mechanics in Fundamental Processes Force-dependent Biological Mechanisms Across Scales: From Single-Molecules to Single-Cells Using the force: Molecular tension probes reveal how forces boost the fidelity of information transfer in signaling
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Colleen Kelly, Ph.D.
University of Massachusetts, Lowell
Ibraheem Alshareedah
University of Buffalo
Chuck Sanders, Ph.D.
Vanderbilt University
Protein Folding Across Methods Protein-RNA Phase-Separated Condensates are Viscoelastic Fluids with Tunable Material Properties CHAIR

Session Topic 10: Designer Proteins Through Genetic Code Expansion

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Kathrin Lang, Ph.D.
Technical University of Munich

Abishek Chatterjee, Ph.D.
Boston College

Nediljko Budisa, Ph.D.
University of Manitoba
Expanding the Genetic Code - Novel Chemistries in Living Systems

Genetically Encoded Chemistries to Read and Write Biology

Recent Advances in Genetic Code Engineering with Non-canonical Aromatic Amino Acids in Escherichia Coli
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Amy Ryan, Ph.D.
University of Pittsburgh
Ahmed Badran, Ph.D.
Broad Institute
Francesca Anson, Ph.D.
University of Massachusetts, Amherst
Optogenetic Approaches for Acute Control of Protein Localization and Degradation Teaching Old Machines New Activities: Novel Technologies for Engineering Cellular Protein Translation Weaponizing Caspases: Investigations to Exploit Caspase-Induced Apoptosis via Intracellular Delivery
Meghan Breen, Ph.D.
Furman University

Session Topic 11: Quaternary Structure: Shape Shifting in the Control of Protein Function

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Constance Jeffery, Ph.D.
University of Illinois Chicago
Yimon Aye, Ph.D.
Kushol Gupta, Ph.D.
University of Pennsylvania
Shapeshifting Moonlighting Proteins Unmasking Proteins' Moonlighting Behaviors Shaped by Ligand-Driven Changes in Functional Networks Solution Conformations of Dimeric Phenylalanine Hydroxylase
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Bostjan Kobe, Ph.D.
University of Queensland

Acacia Dishman, Ph.D.
Medical College of Wisconsin

Eileen Jaffe, Ph.D.
Fox Chase Cancer Center
Signaling by Cooperative Assembly Formation (SCAF) in Innate Immunity and Cell-death Pathways Evolution of Fold-Switching in the Metamorphic Protein XCL1


The Role of Protomer Conformation in Multimer Diversity and Dynamics