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We are excited to bring you this year’s anniversary symposium, comprising 11 exceptional scientific sessions and 10+ award talks that cover a wide range of scientific achievements in the field of protein science. Our program committee, chaired by Jeanne Hardy, Ph.D, has convened a host of stimulating speakers and topical areas of current research. This year’s symposium continues our commitment to open participation, with a number of symposium talks coming from contributed sessions and speakers across a broad range of topics. 

Plenary Speakers

2021 TPS Award Winners

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Bruno Correia, Ph.D.
2021 Protein Science Young Investigator Award 

Toshiya Endo, Ph.D.
2021 Hans Neurath Award
Sheila Jaswal, Ph.D.
2021 Carl Branden Award
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Amy Rosenzweig, Ph.D.
2021 Hans Neurath Award
Janet Smith, Ph.D.
2021 Dorothy Crowfoot Hodgkin Award 
Lei Wang, Ph.D.
2021 Emil Thomas Kaiser Award

2020 and 2019 TPS Award Winners

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Catherine Drennan, Ph.D.
2020 Dorothy Crowfoot Hodgkin Award 

Capturing Snapshots of Ribonucleotide Reductase in Action

Karen Fleming, Ph.D.
2020 Carl Branden Award

Chaperoning Unfolded Membrane Proteins

Martin Gruebele, Ph.D.
2020 Hans Neurath Award 

Protein Folding & Interactions:
From the Computer Into the Test Tube & on to the Cell

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Mohammad Seyedsayamdost, Ph.D.
2020 Protein Science Young Investigator Award  

New Reactions Catalyzed by Metalloenzymes in Natural Product Biosynthetic Pathways

Stephen Sligar, Ph.D.
2020 Christian B. Anfinsen Award

Revealing the Structure & Function of Membrane Proteins

Shuguang Zhang, Ph.D.
2020 Emil Thomas Kaiser Award

Self-Assembling Peptides: 
From a Discovery in a Yeast Protein to Diverse Uses & Beyond

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Minoru Kanehisa, Ph.D.
2019 Carl Branden Award
Toward Understanding the Origin & Evolution of Cellular Organisms & Viruses

Preliminary Program and Speakers

Session Topic 1: Cryo-EM: Beyond Single Particle Reconstruction

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Mimi Ho, Ph.D.
Columbia University
Amédée des Georges, Ph.D.
City University of New York
Radostin Danev, Ph.D.
University of Tokyo
Pushing the Limits of Cryo-EM for G Protein-coupled Receptors

Session Topic 2: New Protein Post-Translational Modifications

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Eranthie Weerapana, Ph.D.
Boston College

Ian Maze, Ph.D.
Icahn School of Medicine

Hening Lin, Ph.D.
Cornell University

Chemical-proteomic Strategies to Investigate Reactive Cysteines Protein Monoaminylation in Brain: Novel Mechanisms of Neural Development, Plasticity & Disease Post-translational Modification Cycles in Cell Signaling & Disease

Session Topic 3: Targeted Protein Degradation

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Angela Cacace, Ph.D.
Nicolas Thomä, Ph.D.
Friedrich Miescher Institute

Session Topic 4: Protein Structures Through the Lens of Machine Learning

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John Jumper, Ph.D.

David Koes, Ph.D.
University of Pittsburgh

Heather Kulik, Ph.D.
An Atomistic View of Deep Protein Structure Prediction What Can Machine Learning & Big Data Teach Us About Metalloenzymes?

Session Topic 5: Protein Evolution, Design and Selection

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Donald Hilvert, Ph.D.
ETH Zurich
Janet Thornton, Ph.D.
Lydia Contreras, Ph.D.
University of Texas at Austin
New Approaches for Identifying & Designing Novel RNA readers

Session Topic 6: Novel Approaches to Observe Proteins in Their Natural Environment

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Rina Rosenzweig, Ph.D.
Weizmann Institute of Science
Miroslava Schaffer, Ph.D.
Max Planck Institute
Lisa Jones, Ph.D.
University of Maryland
The Roles of Hsp40 Chaperones in Health & Disease Cryo-FIB Sample Preparation Methods for Tissue & Cells in Structure Biology Studies at Molecular Resolution Development of In-Cell Protein Footprinting Coupled with Mass Spectrometry for Proteome-Wide Biology

Session Topic 7: Allostery & Dynamics in Protein Function

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Corey Wilson, Ph.D.
Georgia Institute of Technology
Rachelle Gaudet, Ph.D.
Harvard University
Andrew Woolley, Ph.D.
University of Toronto
Transcriptional Programming - Engineering Intelligent Biological Systems Mechanics of an Nramp Family Transition Metal Transporter Harnessing Photo-Switchable Proteins

Session Topic 8: Diffraction Methods are Alive and Well

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Jose Rodriguez, Ph.D.
University of California Los Angeles

Carolyn Larabell, Ph.D.
University of California San Francisco

Eriko Nango, Ph.D.
Tohuku University
New Approaches in Electron Diffraction for Visualizing Molecules with Atomic Detail

Session Topic 9: Measuring Forces of Biological Systems

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Michelle Wang, Ph.D.
Cornell University

Andrea Candelli, Ph.D.

Khalid Salaita, Ph.D.
Emory University

Force-dependent Biological Mechanisms Across Scales: From Single-Molecules to Single-Cells

Session Topic 10: Designer Proteins Through Genetic Code Expansion

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Kathrin Lang, Ph.D.
Technical University of Munich

Abishek Chatterjee, Ph.D.
Boston College

Nediljko Budisa, Ph.D.
University of Manitoba

Session Topic 11: Quaternary Structure: Shape Shifting in the Control of Protein Function

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Eileen Jaffe, Ph.D.
Fox Chase Cancer Center
Constance Jeffery, Ph.D.
University of Illinois Chicago
Yimon Aye, Ph.D.
The Role of Protomer Conformation in Multimer Diversity & Dynamics Unmasking Proteins' Moonlighting Behaviors Shaped by Ligand-Driven Changes in Functional Networks
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Kushol Gupta, Ph.D.
University of Pennsylvania